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- Frederic Adnet, Laurence Le Moyec, Charles E Smith, Michel Galinski, Patricia Jabre, and Frederic Lapostolle.
- SAMU 93-EA 3409, Hôpital Avicenne, 125, Rue de Stalingrad, 93009 Bobigny Cedex, France. frederic.adnet@avc.aphp.fr
- Emerg Med J. 2007 Mar 1; 24 (3): 168-9.
AbstractThe effect of storage temperature on the stability of two succinylcholine chloride solutions (20 and 50 mg/ml) was evaluated. Molecular composition was analysed using nuclear magnetic resonance spectroscopy. At room temperature, the degradation rate constant was 1.2%/month for the 20 mg/ml solution and 2.1%/month for the 50 mg/ml solution. The corresponding monthly degradation rates for the two solutions were 0.18% and 0.30% when stored at 4 degrees C, and 5.4% and 8.1% when stored at 37 degrees C. If a 10% loss of potency is considered acceptable, then the 20 and 50 mg/ml succinylcholine solutions can be stored in emergency resuscitation carts at room temperature for 8.3 and 4.8 months, respectively.
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