• Knut Gjesdal, Gunn E Vist, Einar Bugge, Ole Rossvoll, Marit Johansen, Inger Norderhaug, and Ole-J Ohm.
• Faculty Division Ullevål, Oslo University and Department of Cardiology, Ullevål University Hospital, Oslo, Norway. knut.gjesdal@medisin.uio.no
• Scand. Cardiovasc. J. 2008 Feb 1;42(1):3-8.

ObjectiveTo perform a systematic review of randomized controlled trials (RCTs) on catheter ablation for atrial fibrillation (AF).BackgroundRadiofrequency catheter (RF)-ablation around pulmonary vein ostia and in left atrium may reduce or prevent recurrence of AF, as documented in observational studies and registry reports; however, few RCTs are available.MethodsUsing relevant search phrases, Cochrane Library, MEDLINE and EMBASE were searched for RCTs, last time in May 2007. Titles and abstracts were screened. When entry criteria were fulfilled, full-text papers were read and graded according to quality and relevance.ResultsOne thousand and ninety four abstracts were evaluated, and five RCTs included (578 randomized patients). The studies had moderate quality and relevance, but the results were consistent: ablation is better than drug treatment in preventing AF recurrence; the relative risk (95% CI)) one year after ablation ranged from 0.20 (0.08-0.51) to 0.62 (0.39-0.99).ConclusionsResults from observational and registry studies are confirmed: RF-ablation reduces recurrence rate of AF, and can be done with few serious complications. Limitations are few patients>70 years, and only one year follow-up.

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