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Anesthesia and analgesia · Oct 2011
The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs.
- Javier Casanova, Ignacio Garutti, Carlos Simon, Ana Giraldez, Beatriz Martin, Guillermo Gonzalez, Leire Azcarate, and Elena Vara.
- Department of Anesthesiology, Gregorio Maranon University General Hospital, c/querol 5,3°c, Madrid, 28033, Spain. Kassss1@yahoo.es
- Anesth. Analg.. 2011 Oct 1;113(4):742-8.
BackgroundIschemia-reperfusion lung injury is doubly important in thoracic surgery because of the associated ventilation damage to 1 lung. In this study we evaluated the cytoprotective effects of sevoflurane in a pulmonary autotransplant model in pigs.MethodsTwenty Large White pigs undergoing pneumonectomy plus lung autotransplant were divided into 2 10-member groups on the basis of the anesthetic received (propofol or sevoflurane). Proinflammatory mediators, oxidative stress, nitric oxide metabolism, and hemodynamic and blood variables were measured at 5 different time points.ResultsThere was an increase of oxidative stress markers and proinflammatory mediators in the propofol group, whereas the hemodynamic variables were similar in both groups.ConclusionsWe demonstrated that sevoflurane decreased the inflammatory response and oxidative stress in a live ischemia-reperfusion lung model.
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