• The EMBO journal · Mar 2007

    Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation.

    • Christian Proepper, Svenja Johannsen, Stefan Liebau, Janine Dahl, Bianca Vaida, Juergen Bockmann, Michael R Kreutz, Eckart D Gundelfinger, and Tobias M Boeckers.
    • Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.
    • EMBO J. 2007 Mar 7;26(5):1397-409.

    AbstractSynaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein-1 (Abi-1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi-1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi-1, Eps8 and Sos-1. Abi-1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi-1 co-immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E-box-regulated gene transcription. Downregulation of Abi-1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi-1 has the opposite effect. Data show that Abi-1 can act as a specific synapto-nuclear messenger and is essentially involved in dendrite and synapse formation.

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