• Anesthesia and analgesia · Apr 2010

    The influence of age on sample size calculation in acute pain trials using morphine consumption as an end point.

    • Mark Reeves.
    • Rural Clinical School, University of Tasmania, Burnie, Tasmania, Australia. mark.reeves@dhhs.tas.gov.au
    • Anesth. Analg. 2010 Apr 1;110(4):1186-90.

    BackgroundMany trials in acute postoperative pain use morphine consumption as an end point. Age has been shown to have a significant influence on morphine consumption but is rarely considered in end point analysis.MethodsSimulation was used to investigate the effect of age on the power of various sample sizes to detect differences in morphine consumption in control and study groups.ResultsThe sample sizes required for 80% power were approximately twice that predicted by a sample size program when comparing morphine consumption using a t test without adjustment for age.ConclusionsThe model suggests that variations in age have a profound effect on sample size. Researchers may need to account for this to prevent both type 1 and type 2 error.

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