• Ugeskrift for laeger · Jun 2011

    [Tapentadol is a new, strongly efficative analgeticum with dual effect mechanisms].

    • Camilla Staahl, Asbjørn Mohr Drewes, and Niels-Henrik Jensen.
    • Grünenthal Denmark ApS, Arne Jacobsens Allé 7, 2300 København S, Denmark. camilla.staahl@grunenthal.com
    • Ugeskr. Laeg. 2011 Jun 20;173(25):1796-9.

    AbstractTapentadol exerts its analgesic effects through opioid receptor agonism and noradrenaline reuptake inhibition in the central nervous system. Clinical studies show that tapentadol effectively relieves moderate to severe pain in both post-operative and chronic pain. In these trials with equianalgesic doses of tapentadol and oxycodone, treatment with tapentadol was associated with significantly fewer gastrointestinal-related adverse events. Furthermore, in a placebo-controlled study, tapentadol has shown good efficacy in painful diabetic polyneuropathy.

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