• B P Krieger, J Isber, A Breitenbucher, G Throop, and P Ershowsky.
• Division of Pulmonary Intensive Care, Mount Sinai Medical Center, Miami Beach, Fla, USA.
• Chest. 1997 Oct 1;112(4):1029-34.

Study ObjectivesTo determine the usefulness of serial measurements of the rapid-shallow-breathing index (f/VT) as a predictor for successfully weaning elderly medical patients from mechanical ventilator support using a threshold value (< or =130) derived specifically for this population.DesignProspective observational study using parameters suggested from retrospective analysis.SettingMedical ICUs of a university-affiliated private teaching hospital.PatientsUsing data obtained from a retrospective analysis of 10 medical patients > or =70 years old who had failed weaning, 49 additional medical patients older than 70 years were studied prospectively.InterventionsStandard weaning parameters were determined using a hand-held spirometer. Respiratory rate (f, breaths/min) and tidal volume (VT, liters) were measured at the beginning of a spontaneous breathing trial and hourly thereafter for up to 5 h using the same hand-held spirometer.Measurements And ResultsRetrospective analysis showed that the published threshold value for f/VT (< or =105) had poor predictability for weaning success when measured at the beginning of the weaning trial. In the 9 of 10 patients who failed to wean in the retrospective review, the f/VT increased to > 130 as the trial progressed over 2 to 3 h. Using an f/VT < or =130 as the threshold value for prospectively predicting successful weaning, the diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value increased from 84%, 92%, 57%, 87%, and 67%, respectively, when measured at the beginning of the weaning trial to 92%, 93%, 89%, 97%, and 80%, respectively, when measured 3 h later. The area under the receiver operating characteristic curve for f/VT also improved from 0.81 to 0.93.ConclusionsSerial measurements of the rapid-shallow-breathing index in medical elderly patients during a period of spontaneous breathing can accurately predict the ability to be successfully weaned from mechanical ventilator support.

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