• Ugeskrift for laeger · Jun 2005

    [Fibrinogen substitution. Use in the treatment of bleeding due to lack of fibrinogen].

    • Jørgen Ingerslev and Benny Sørensen.
    • Klinisk Biokemisk Afdeling, Center for Haemofili og Trombose, Skejby Sygehus, Aarhus Universitetshospital, DK-8200 Arhus. ingerslev@ki.au.dk
    • Ugeskr. Laeg. 2005 Jun 20;167(25-31):2759-61.

    AbstractFibrinogen is critically important in haemostasis. The concentration of fibrinogen in plasma is usually between 2 and 4 g/l (6-13 micromol/l). No detectable fibrinogen is found in afibrinogenaemia, a condition characterised by dramatic bleeding, while dys- and hypofibrinogenaemia have a lower-than-normal activity of functional fibrinogen. Acquired fibrinogen deficiency may occur with a variety of underlying pathologies. Fibrinogen substitution may be done with fresh-frozen plasma, cryoprecipitate and virally inactivated concentrates of fibrinogen.

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