• Int. J. Neurosci. · Oct 2013

    Case Reports

    Paucisymptomatic Marchiafava-Bignami disease with relevant diffusion-weighted MRI lesions.

    • Maria Giovanna Sarpa, Davide Ferrazzoli, Roberto Massa, Francesco Garaci, Francesca Izzi, Andrea Romigi, Claudio Liguori, and Fabio Placidi.
    • 1Department of Neuroscience, University of Rome Tor Vergata , Rome , Italy.
    • Int. J. Neurosci. 2013 Oct 1;123(10):738-40.

    AbstractMarchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelization and necrosis of the corpus callosum. Diffusion-weighted (DW) MRI may reveal the lesions in patients showing serious clinical manifestations, high mortality rate and severe cognitive sequelae, though some cases with good outcome have been reported. We describe a case of a man with a history of chronic alcohol abuse associated with malabsorption; the man presented mild clinical signs on the first neurological exam, despite the presence of DW-MRI lesions, bilaterally involving entire corpus callosum, that are compatible with MBD diagnosis.

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