• Minerva anestesiologica · Dec 2007

    Review

    My brother has severe sepsis--should he receive Xigris?

    • P M Suter.
    • University of Geneva, Switzerland. Peter.Suter@medecine.unige.ch
    • Minerva Anestesiol. 2007 Dec 1;73(12):647-50.

    AbstractSix years ago, a publication in a quite well known scientific medical journal brought hope and a good dose of optimism to sepsis therapy and the critical care community. For the first time, a careful randomized controlled trial in patients with severe sepsis or septic shock seemed to show a clearly beneficial effect of a new drug, i.e. of activated recombinant human protein C. This new treatment possibility was welcomed as an important breakthrough and a hope for a better management of a deadly disease. However, further evaluation of the results of the trial and new investigations did not confirm entirely the initial optimism. As a consequence, the adequate indications for this expensive drug remain controversial.

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