• Intensive care medicine · Jan 2009

    Clinical Trial

    Effects of mannitol alone and mannitol plus furosemide on renal oxygen consumption, blood flow and glomerular filtration after cardiac surgery.

    • Bengt Redfors, Kristina Swärd, Johan Sellgren, and Sven-Erik Ricksten.
    • Department of Cardiothoracic Anaesthesia and Intensive Care, Sahlgrenska University Hospital, 41345, Göteborg, Sweden.
    • Intensive Care Med. 2009 Jan 1; 35 (1): 115-22.

    ObjectiveImbalance of the renal medullary oxygen supply/demand relationship can cause hypoxic medullary damage and ischaemic acute renal failure (ARF). The use of mannitol for prophylaxis/treatment of clinical ischaemic ARF is controversial and the effect of mannitol on renal oxygenation in man has not yet been investigated. We evaluated the effects of mannitol on renal oxygen consumption (RVO(2))(,) renal blood flow (RBF) and glomerular filtration rate (GFR) in postoperative patients.DesignProspective interventional study.SettingUniversity hospital cardiothoracic ICU.PatientsTen uncomplicated mechanically ventilated and sedated postcardiac surgery patients with preoperatively normal renal function.InterventionsMannitol infusion (225 mg/kg + 75 mg/kg/h) and combined mannitol and furosemide infusion (0.25 mg/kg + 0.25 mg/kg/h).Measurements And ResultsSystemic haemodynamics were evaluated by a pulmonary artery catheter. RBF and GFR were measured by the renal vein thermodilution technique and by renal extraction of (51)Cr-EDTA, respectively. Mannitol increased urine flow (60%), GFR (20%) and filtration fraction (FF) (20%) with no change in RBF. This was accompanied by an increase in renal sodium reabsorption (18%), RVO(2) (19%) and renal oxygen extraction (21%). When combined with mannitol, furosemide normalised sodium reabsorption, RVO(2), renal oxygen extraction with no change in RBF, while GFR and FF were still elevated compared to control.ConclusionsIn patients with normal renal function, mannitol increases GFR, which increases tubular sodium load, sodium reabsorption and RVO(2) after cardiac surgery. The lack of effect on RBF, indicates that mannitol impairs the renal oxygen supply/demand relationship. Furosemide normalised renal oxygenation when combined with mannitol.

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