• Anesthesia and analgesia · Aug 2004

    Case Reports

    Hepatitis after sevoflurane exposure in an infant suffering from primary hyperoxaluria type 1.

    • Alexander Reich, Anne Schulze Everding, Monika Bulla, Olaf Anselm Brinkmann, and Hugo Van Aken.
    • Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Münster, Albert Schweitzer-Strasse 33, D-48129 Münster, Germany. reich@anit.uni-muenster.de
    • Anesth. Analg. 2004 Aug 1;99(2):370-2, table of contents.

    AbstractAn 11-mo-old child with primary hyperoxaluria was scheduled for a nephroureteromia procedure. Anesthesia was induced and maintained with sevoflurane. Two days after the operation, a hepatomegaly was diagnosed, and a considerable increase in liver enzymes was observed. These pathologic findings disappeared without treatment within 7 days. In a subsequent operation 2 wk later, general anesthesia was performed (sevoflurane was avoided). After the second operation, no pathologic findings could be detected. Nothing in this patient's disease or the conduct of the anesthesia suggested a cause for the injury other than an idiosyncratic response to sevoflurane.

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