• The Journal of nutrition · Oct 1999

    Oral administration of a glutamine-enriched diet before or after endotoxin challenge in aged rats has limited effects.

    • M C Farges, M P Bérard, F Raul, J P Cézard, B Joly, P Davot, M P Vasson, and L Cynober.
    • Laboratoire de Biochimie, Biologie Moléculaire et Nutrition EA 2416, Faculté de Pharmacie et Centre de Recherche en Nutrition Humaine, 28 place Henri Dunant, BP 38, 63001 Clermont-Ferrand, France.
    • J. Nutr. 1999 Oct 1;129(10):1799-806.

    AbstractNumerous studies indicate beneficial effects of glutamine (Gln) in many models of catabolic adult rats. No data were available for aged rats. The effects of oral L-Gln-enriched diet were tested in endotoxemic 24-mo old rats. First, rats received for 7 d (from d0 to d7) an oral diet supplemented with either L-Gln [1g/(kg. d)] or casein (Cas: isonitrogenous supply) prior to lipopolysaccharide (LPS) challenge. The rats were then killed after 24 h food deprivation (from d7 to d8). Endotoxemia induced a catabolic response as shown by muscle glutamine depletion, hyperphenylalaninemia, small bowel atrophy and impaired functionality and bacterial translocation. The Gln-enriched diet did not prevent muscle Gln depletion but significantly (P

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