• Dvora Frankenthal, Yaffa Lerman, Edward Kalendaryev, and Yehuda Lerman.
• Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Tel Aviv University, Tel Aviv, Israel.
• J Am Geriatr Soc. 2014 Sep 1;62(9):1658-65.

ObjectivesTo assess the effect of a Screening Tool of Older Persons potentially inappropriate Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) medication intervention on clinical and economic outcomes.DesignParallel-group randomized trial.SettingChronic care geriatric facility.ParticipantsResidents aged 65 and older prescribed with at least one medication (N = 359) were randomized to receive usual pharmaceutical care or undergo medication intervention.InterventionScreening medications with STOPP/START criteria followed up with recommendations to the chief physician.MeasurementsThe outcome measures assessed at the initiation of the intervention and 1 year later were number of hospitalizations and falls, Functional Independence Measure (FIM), quality of life (measured using the Medical Outcomes Study 12-item Short-Form Health Survey), and costs of medications.ResultsThe average number of drugs prescribed was significantly lower in the intervention than in the control group after 1 year (P < .001). The average drug costs in the intervention group decreased by 103 shekels (US$29) per participant per month (P < .001). The average number of falls in the intervention group dropped significantly (P = .006). Rates of hospitalization, FIM scores, and quality of life measurements were similar for both groups.ConclusionImplementation of STOPP/START criteria reduced the number of medications, falls, and costs in a geriatric facility. Their incorporation in those and similar settings is recommended.© 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

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