• J. Med. Chem. · Mar 2015

    Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.

    • Jason G Kettle, Peter Ballard, Catherine Bardelle, Mark Cockerill, Nicola Colclough, Susan E Critchlow, Judit Debreczeni, Gary Fairley, Shaun Fillery, Mark A Graham, Louise Goodwin, Sylvie Guichard, Kevin Hudson, Richard A Ward, and David Whittaker.
    • Oncology iMed, AstraZeneca, Alderley Park, Macclesfield, SK10 4TG, United Kingdom.
    • J. Med. Chem. 2015 Mar 26;58(6):2834-44.

    AbstractPotent and selective inhibitors of Dyrk1B kinase were developed to explore the hypothesis, based on siRNA studies, that Dyrk1B may be a resistance mechanism in cells undergoing a stress response.

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