-
Randomized Controlled Trial Clinical Trial
Influence of neostigmine on postoperative vomiting.
- M J King, R Milazkiewicz, F Carli, and A R Deacock.
- Department of Anaesthesia, Royal National Orthopaedic Hospital, Stanmore, Middlesex.
- Br J Anaesth. 1988 Oct 1;61(4):403-6.
AbstractThirty-eight patients undergoing elective hip or knee surgery were randomly allocated to two groups. Neuromuscular blockade in group A was antagonized with neostigmine 2.5 mg and atropine 1.2 mg, while group B received no drugs to facilitate antagonism of blockade. The incidence and severity of postoperative nausea and vomiting were assessed 24 h after operation. Nausea and vomiting were significantly reduced in group B. The incidence of nausea in group A was 68%, compared with 32% in group B (P less than 0.01). The incidence of vomiting was 47% in group A, compared with 11% in group B (P less than 0.02). A significant relationship was shown between postoperative emetic symptoms and the antagonism of neuromuscular blockade by neostigmine and atropine.
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