• Int Rev Neurobiol · Jan 2012

    Review

    Multimodal imaging and image analysis techniques for neuromodulation.

    • M Mallar Chakravarty.
    • Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. mallar_chakravarty@camh.net
    • Int Rev Neurobiol. 2012 Jan 1;107:235-52.

    AbstractFunctional neurosurgical procedures used to treat the debilitating motor symptoms of Parkinson's disease and that target small subcortical structures have typically relied on semi-qualitative manual approaches that rely upon the establishing qualitative between volumetric imaging data and print atlases. This chapter reviews many new high -precision and -accuracy techniques that can be used for the full automated localization of these targets. These techniques rely on the a priori development of neuroanatomical atlases derived from magnetic resonance imaging data, high-resolution identification of subcortical structures from histology, and spatially localized data bases of intra-operative recordings and successful surgical outcomes. Other novel structural and functional MRI techniques that allow for the direct visualization of thalamic sub nuclei are also reviewed.Copyright © 2012 Elsevier Inc. All rights reserved.

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