• J B Dijkstra, M P Van Boxtel, P J Houx, and J Jolles.
• Brain and Behavior Research Institute, Maastricht University, The Netherlands.
• J Am Geriatr Soc. 1998 Oct 1;46(10):1258-65.

ObjectiveTo evaluate the factor 'operation under general anesthesia' as a possible risk factor for age-related cognitive decline.DesignA retrospective, population-based, cross-sectional study.SettingMaastricht Aging Study (MAAS), Maastricht, The Netherlands.Participants1257 normal healthy subjects aged 24 to 86 years. Of the 1257 healthy subjects, 946 subjects appeared to have undergone at least one operation under general anesthesia.MeasurementsThe history of an operation under general anesthesia, number of operations, duration of anesthesia, cognitive performance, subjective health, and subjective memory were measured.ResultsA history of an operation under general anesthesia, the number of operations, and the total duration of anesthesia significantly contributed to the number of subjective health-related complaints but did not predict cognitive performance or memory complaints. Subjects with a history of an operation under general anesthesia felt less healthy than subjects who had never undergone an operation under general anesthesia. No interactions with age were found.ConclusionThe present study found no support for the notion that a history of an operation under general anesthesia is a determinant or risk factor for accelerated age-related cognitive decline.

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