• S Nagano, S H Kim, S Tokunaga, K Arai, M Fujiki, and K Misumi.
• Department of Veterinary Clinical Science, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
• Res. Vet. Sci. 2011 Dec 1;91(3):482-5.

AbstractWe investigated whether matrix metalloproteinase (MMP)-9 expression in the cerebrospinal fluid (CSF) of dogs with intervertebral disc herniation (IVDH) is associated with the severity of neurological signs and prognosis. CSF from the cisterna magna (C-CSF) and the lumbar spine (L-CSF) of 34 dogs with IVDH was analyzed using zymography. Activity of MMP-9 in L-CSF was detected in 6 of 34 dogs with IVDH, often for more than 7 days after injury. MMP-9 activity was not detected from any of the C-CSF samples. Of the six cases that were MMP-9 positive, all four cases with grade V that had loss of deep pain were non-ambulatory 6 months after treatment. The remaining two cases with grade III and IV could recover mobility. In dogs with grade V thoracolumbar IVDH, MMP-9 expression in the CSF may indicate severe spinal cord injury with poor prognosis.Copyright © 2010 Elsevier Ltd. All rights reserved.

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