• Curr Opin Invest Dr · Jan 2006

    Review

    The mechanism of action of gabapentin in neuropathic pain.

    • J Kenneth Baillie and Ian Power.
    • Department of Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Street, Edinburgh EH16 4SA, UK. j.k.baillie@doctors.org.uk
    • Curr Opin Invest Dr. 2006 Jan 1;7(1):33-9.

    AbstractNeuropathic pain is a common and potentially treatable cause of considerable lifelong morbidity. Effective pharmacological treatments are scarce, but one group of drugs that has shown promise is the antiepileptics. Gabapentin has become popular as a first-line treatment for neuropathic pain because of its efficacy as an antineuropathic agent and relatively benign side-effect profile. However, its mechanism of action is far from clear. This review discusses the available evidence for the postulated mechanisms of action of gabapentin. Understanding the mechanism of action of this agent may well lead to the development of safer and more effective antineuropathic drugs.

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