• Kyle B Walsh, Alexander H Toledo, Fernando A Rivera-Chavez, Fernando Lopez-Neblina, and Luis H Toledo-Pereyra.
• Michigan State University College of Human Medicine, East Lansing, Michigan 49008, USA.
• Exp Clin Transplant. 2009 Jun 1;7(2):78-93.

AbstractLiver ischemia and reperfusion--which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant)--have been the focus of many investigations in recent years. Although the mechanisms of ischemia-reperfusion injury are numerous and complex, many advances in treatment have been made. The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. To provide a unique analysis and evaluation, we emphasized the most recent pertinent investigations of the last decade. Specific topics addressed include reactive oxygen species, nitric oxide, toll-like receptors, ischemic preconditioning, T cells, heme oxygenase-1, heat shock proteins, erythropoietin, selectins, protein kinases, matrix metalloproteinases, and cytokines.

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