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Int. J. Tuberc. Lung Dis. · Feb 2012
Comparative StudyFluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis.
- C Pierre-Audigier, C Surcouf, V Cadet-Daniel, A Namouchi, S Heng, A Murray, B Guillard, and B Gicquel.
- Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France.
- Int. J. Tuberc. Lung Dis. 2012 Feb 1;16(2):221-3, i-ii.
AbstractIn a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.
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