• George Dimopoulos, Despoina Koulenti, Stijn Blot, Yasser Sakr, Antonio Anzueto, Claudia Spies, Jordi Solé Violán, Daniel Kett, Apostolos Armaganidis, Claude Martin, Jean Louis Vincent, and Extended Prevalence of Infection in Intensive Care Study Investigators.
• J Am Geriatr Soc. 2013 Dec 1;61(12):2065-71.

ObjectivesTo determine the effect of age on patterns of infection and on outcomes in individuals with infection.DesignAnalysis of data from an international, observational, point-prevalence study: Extended Prevalence of Infection in Intensive Care (EPIC II).SettingIntensive care units (ICUs; N=1,265) in 75 countries.ParticipantsAll adults present in a participating ICU on May 8, 2007. Individuals with an infection were included and classified according to age (18–44, 45–64, 65–74, 75–84, ≥85).MeasurementsDemographic, physiological, bacteriological, and therapeutic data were collected on the day of the study. Outcome data were collected until hospital discharge or for 60 days.ResultsOf the 13,796 adults enrolled in EPIC II, 7,087 (51.4%) had an infection. Of these, 330 (4.7%) were aged 85 and older, 1,405 (19.8%) were 75 to 84, 1,713 (24.2%) were 65 to 74, 2,358 (33.3%) were 45 to 64, and 1,281 (18.1%) were 18 to 44. Severity of illness did not differ between groups. Those aged 85 and older had fewer bloodstream infections than those younger than 75, fewer central nervous system infections than those who were younger than 65, and more abdominal infections than those who were younger than 45. A microbiological diagnosis was established less frequently in participants aged 85 and older than in younger participants. Gram-negative microorganisms were more frequently isolated in those aged 85 and older than in other groups. ICU and hospital mortality were significantly higher in participants aged 85 and older than in those who were younger than 65.ConclusionA large proportion of individuals in the ICU with infection are aged 65 and older. Patterns of infection, including site and type of microorganism, vary according to age. Being aged 85 and older was an independent risk factor for mortality in individuals in the ICU with infection.© 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society.

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