• Yu-Guang Xu, Qu-Lian Guo, and Yan-Qing Wang.
• Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
• Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Feb 1;29(1):94-6.

ObjectiveTo observe the effects of desflurane on A-line ARX Index (AAI), QEEG, MAP and HR, and to investigate the feasibility of AAI, QEEG, MAP and HR in monitoring the depth of anesthesia with desflurane.MethodsThirty patients classified as ASA physical status I approximately II were scheduled for elective lower abdominal surgery. Anesthesia was induced with propofol and vecuronum. After the tracheal intubation, the lungs were ventilated with desflurane in oxygen. End-tidal desflurane concentrations were maintained at 0.8, 1.0 and 1.3 MAC for 20 minutes, respectively. The parameters of record included AAI, BIS (bispectral index), SEF (95% spectral edge freqency), MF (midian freqency), MAP and HR.ResultsAAI, BIS, SEF and MF significantly decreased in a linear manner (r = 0.830, 0.930, 0.803, and 0.885, respectively, P < 0.01) with increasing end-tidal concentration of desflurane range of 0.8 approximately 1.3 MAC. MAP and HR did not change much. HR increased significantly at concentration 1.3 MAC than that of 1.0 MAC.ConclusionWithin end-tidal desflurane concentration range 0.8 approximately 1.3 MAC, both AAI and parameters derived from EEG (such as BIS, SEF, MF) can serve as parameters in monitoring the depth of anesthsia with desflurane, while MAP and HR can not.

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