• Anaesthesia · Jan 2013

    Review Meta Analysis

    Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis.

    • E Albrecht, K R Kirkham, S S Liu, and R Brull.
    • Department of Anaesthesia, Toronto Western Hospital, University of Toronto, Toronto, Canada. eric.albrecht74@gmail.com 
    • Anaesthesia. 2013 Jan 1;68(1):79-90.

    AbstractIntravenous magnesium has been reported to improve postoperative pain; however, the evidence is inconsistent. The objective of this quantitative systematic review is to evaluate whether or not the peri-operative administration of intravenous magnesium can reduce postoperative pain. Twenty-five trials comparing magnesium with placebo were identified. Independent of the mode of administration (bolus or continuous infusion), peri-operative magnesium reduced cumulative intravenous morphine consumption by 24.4% (mean difference: 7.6 mg, 95% CI -9.5 to -5.8 mg; p < 0.00001) at 24 h postoperatively. Numeric pain scores at rest and on movement at 24 h postoperatively were reduced by 4.2 (95% CI -6.3 to -2.1; p < 0.0001) and 9.2 (95% CI -16.1 to -2.3; p = 0.009) out of 100, respectively. We conclude that peri-operative intravenous magnesium reduces opioid consumption, and to a lesser extent, pain scores, in the first 24 h postoperatively, without any reported serious adverse effects.Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.

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    This article appears in the collections: Magnesium the new 'roid and Meta-analyses.

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