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Crit. Rev. Oncol. Hematol. · Nov 2011
ReviewCirculating microRNAs: Association with disease and potential use as biomarkers.
- Glen Reid, Michaela B Kirschner, and Nico van Zandwijk.
- Asbestos Diseases Research Institute (ADRI), Bernie Banton Centre, University of Sydney, Concord, Australia. glen.reid@sydney.edu.au
- Crit. Rev. Oncol. Hematol. 2011 Nov 1;80(2):193-208.
AbstractThe control of gene expression by microRNAs influences many cellular processes and has been implicated in the control of many (patho)physiological states. Recently, microRNAs have been detected in serum and plasma, and circulating microRNA profiles have now been associated with a range of different tumour types, diseases such as stroke and heart disease, as well as altered physiological states such as pregnancy. Here we review the disease-specific profiles of circulating microRNAs, and the methodologies used for their detection and quantification. We also discuss possible functions of circulating microRNAs and their potential as non-invasive biomarkers.Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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