• J. Assist. Reprod. Genet. · Sep 2011

    Randomized Controlled Trial

    Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.

    • Ozlem Gun Eryilmaz, Aysun Devran, Esma Sarikaya, Fatma Nur Aksakal, Leyla Mollamahmutoğlu, and Nedim Cicek.
    • IVF Department, Zekai Tahir Burak Women Education and Research Hospital, Devlet Mah. Subay Loj. Hızırreis Apt. No: 19/11, Yenisehir, Ankara, Turkey. drozlemgun@yahoo.com
    • J. Assist. Reprod. Genet. 2011 Sep 1;28(9):815-20.

    PurposeWe aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin.MethodsA total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups.ResultsSleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively.ConclusionIVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

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