• Xi-ying Zhang, Qu-lian Guo, Jiang-ping Wang, Yi-ru Tong, Xing-xing Zhou, and Li-dan Jiang.
• Department of Anesthesiology, Children's Hospital of Hunan Province, Changsha 410007, China.
• Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Jun 1;32(3):503-6.

ObjectiveTo observe the effect of sevoflurane on the induction and maintenance of anaesthesia in children, and to evaluate its safety and effectiveness.MethodsForty child patients who conformed to the selection standard were operated under anaesthesia with intubation.Without premedicant, all the patients inhaled 100% oxygen(1L/min) and sevoflurane by mask, and escalated the concentration of sevoflurane (to the maximum concentration 7%) until the lash reflex disappeared, and the maintenance concentration was controlled under 4%. All the patients were intubated, together with vecuronium 0.1mg/kg.ResultsWith little tract excretion, the achievement ratio of induction by sevoflurane was 100%, and the children tolerated well. With stable hemodynajmics,1% approximately 4.0% maintenance concentration of sevoflurane during the operation showed effective anaesthesia, no decreased heart rate or blood pressure appeared, and all the patients' body temperature was normal.ConclusionSevoflurane for children induction can bring fewer stimuli in the respiratory tract,less cardiac vascular inhibition and palinesthesia time. Anaesthesia in children induced by sevoflurane is safe and effective.

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