Randomized, double-blind, placebo-controlled study to

European heart journal · Sep 2007

Randomized Controlled Trial Multicenter Study

Randomized, double-blind, placebo-controlled study to evaluate the effect of two dosing regimens of darbepoetin alfa in patients with heart failure and anaemia.

Anaemia is common in chronic heart failure (CHF) and associated with worse outcome. This randomized, double-blind, placebo-controlled study evaluated the effect of two darbepoetin alfa dosing regimens on haemoglobin (Hb) rate of rise and clinical effects in patients with CHF and anaemia. ⋯ In this study of patients with CHF and anaemia, treatment with darbepoetin alfa raised Hb using different dosing regimens. Darbepoetin alfa improved some quality of life indices, but its safety requires further exploration. Larger trials are needed to determine the effects on long-term morbidity and mortality.

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- Dirk J van Veldhuisen, Kenneth Dickstein, Alain Cohen-Solal, Dirk J A Lok, Scott M Wasserman, Nigel Baker, Dylan Rosser, John G F Cleland, and Piotr Ponikowski.
- Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands. d.j.van.veldhuisen@thorax.umcg.nl
- Eur. Heart J. 2007 Sep 1;28(18):2208-16.
AimsAnaemia is common in chronic heart failure (CHF) and associated with worse outcome. This randomized, double-blind, placebo-controlled study evaluated the effect of two darbepoetin alfa dosing regimens on haemoglobin (Hb) rate of rise and clinical effects in patients with CHF and anaemia.Methods And ResultsPatients with CHF (>or=3 months), left ventricular ejection fraction (LVEF) ConclusionIn this study of patients with CHF and anaemia, treatment with darbepoetin alfa raised Hb using different dosing regimens. Darbepoetin alfa improved some quality of life indices, but its safety requires further exploration. Larger trials are needed to determine the effects on long-term morbidity and mortality.

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Randomized, double-blind, placebo-controlled study to evaluate the effect of two dosing regimens of darbepoetin alfa in patients with heart failure and anaemia.

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