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- Fumio Omata, Minoru Shibata, Masayuki Nakano, Joshua L Jacobs, Yasuharu Tokuda, Tokuda Yasuharu, Katsuhide Fukutake, Osamu Takahashi, and Tsuguya Fukui.
- Gastroenterology Center, St Luke's International Hospital, Tokyo. f_omata@mac.com
- Intern. Med. 2009 Jan 1;48(22):1945-9.
AbstractA 49-year-old asthmatic woman with a history of drug allergy to aspirin and penicillin presented to the hospital with fever, dark urine, general exanthema and fatigue. Physical examination revealed jaundice. She had been taking four different over-the-counter drugs. Laboratory examination showed eosinophilia, elevated Ig E, hyperbilirubinemia and elevated liver function tests. HBs Ag, anti-HCV Ab and Ig M anti-HA were negative. She was initially diagnosed with drug-induced hepatitis and was treated with steroids. However, liver dysfunction with eosinophilia relapsed after discontinuing steroids. Liver biopsy revealed eosinophilic infiltration. Steroids were discontinued after the start of 6-mercaptopurine.
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