• Peter Dahlem, Wim M C van Aalderen, Marjorie de Neef, Marcel G W Dijkgraaf, and Albert P Bos.
• Division of Pediatric Intensive Care, Department of Pediatrics, Emma Children's Hospital, Academic Medical Center of the University of Amsterdam, The Netherlands.
• Crit. Care Med. 2004 Apr 1; 32 (4): 105510601055-60.

ObjectivesTo investigate whether aerosolized prostacyclin improves oxygenation in children with acute lung injury.DesignDouble-blind, randomized, and placebo-controlled trial.SettingPediatric intensive care unit at a university hospital.PatientsFourteen children with acute lung injury defined by the criteria of an American-European Consensus Conference.InterventionsAerosolized prostacyclin (epoprostenol sodium) by stepwise increments of different doses (10, 20, 30, 40, and 50 ng x kg x min) vs. aerosolized normal saline (placebo).Measurements And Main ResultsBefore the start of the study, and before and after each dose of prostacyclin/placebo, the following variables were measured: arterial blood gases, heart rate, mean arterial blood pressure, and ventilator settings required. Changes in oxygenation were measured by calculation of the oxygenation index (mean airway pressure x 100 x Pao2/Fio2). After treatment with aerosolized prostacyclin, there was a significant 26% (interquartile range, 3%, 35%) improvement in oxygenation index at 30 ng x kg x min compared with placebo (p =.001). The response to prostacyclin was not the same in all children. We saw an improvement of > or = 20% in eight of 14 children (i.e., responders), and the number needed to treat was 1.8 (95% confidence interval, 1.2-3.2). No adverse effects were observed.ConclusionsAerosolized prostacyclin improves oxygenation in children with acute lung injury. Future trials should investigate whether this treatment will positively affect outcome.

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