• Br J Anaesth · Apr 1990

    Comparative Study Clinical Trial Controlled Clinical Trial

    Clinical observations on the neuromuscular blocking action of Org 9426, a new steroidal non-depolarizing agent.

    • J M Wierda, A P de Wit, K Kuizenga, and S Agoston.
    • Institute for Experimental Anaesthesiology, University of Groningen, The Netherlands.
    • Br J Anaesth. 1990 Apr 1;64(4):521-3.

    AbstractThe neuromuscular blocking effects of Org 9426, the 2-morpholino, 16-allyl-pyrrolidino derivative of the 3-desacetoxy analogue of vecuronium have been investigated in anaesthetized patients. Based on data from a pilot study, two doses, 250 and 500 micrograms kg-1 (estimated as the ED90 and 2 x ED90, respectively) were chosen. Org 9426 appeared to be six to eight times less potent than vecuronium and showed a faster rate of development of neuromuscular block, with good to excellent intubation conditions within 60 s after administration of a dose of 500 micrograms kg-1. The duration of action and the recovery index appeared to be similar to those of vecuronium. Side effects were not noted. Org 9426 may have advantages over existing non-depolarizing neuromuscular blocking agents with respect to rate of development of good intubating conditions, and is stable in aqueous solutions.

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