• Resuscitation · May 2016

    The Effect of Head Up Cardiopulmonary Resuscitation on Cerebral and Systemic Hemodynamics.

    • Hyun Ho Ryu, Johanna C Moore, Demetris Yannopoulos, Michael Lick, Scott McKnite, Sang Do Shin, Tae Yun Kim, Anja Metzger, Jennifer Rees, Adamantios Tsangaris, Guillaume Debaty, and Keith G Lurie.
    • School of Medicine, Chonnam National University, Department of Emergency Medicine, Chonnam National University Hospital. Electronic address: oriryu@naver.com.
    • Resuscitation. 2016 May 1; 102: 29-34.

    AimChest compressions during cardiopulmonary resuscitation (CPR) increase arterial and venous pressures, delivering simultaneous bidirectional high-pressure compression waves to the brain. We hypothesized that this may be detrimental and could be partially overcome by elevation of the head during CPR.MeasurementsFemale Yorkshire farm pigs (n=30) were sedated, intubated, anesthetized, and placed on a table able to elevate the head 30° (15cm) (HUP) and the heart 10° (4cm) or remain in the supine (SUP) flat position during CPR. After 8minutes of untreated ventricular fibrillation and 2minutes of SUP CPR, pigs were randomized to HUP or SUP CPR for 20 more minutes. In Group A, pigs were randomized after 2minutes of flat automated conventional (C) CPR to HUP (n=7) or SUP (n=7) C-CPR. In Group B, pigs were randomized after 2minutes of automated active compression decompression (ACD) CPR plus an impedance threshold device (ITD) SUP CPR to either HUP (n=8) or SUP (n=8).ResultsThe primary outcome of the study was difference in CerPP (mmHg) between the HUP and SUP positions within groups. After 22minutes of CPR, CerPP was 6±3mmHg in the HUP versus -5±3 in the SUP (p=0.016) in Group A, and 51±8 versus 20±5 (p=0.006) in Group B. Coronary perfusion pressures after 22minutes were HUP 6±2 vs SUP 3±2 (p=0.283) in Group A and HUP 32±5 vs SUP 19±5, (p=0.074) in Group B. In Group B, 6/8 pigs were resuscitated in both positions. No pigs were resuscitated in Group A.ConclusionsThe HUP position in both C-CPR and ACD+ITD CPR significantly improved CerPP. This simple maneuver has the potential to improve neurological outcomes after cardiac arrest.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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