• J. Chem. Neuroanat. · Sep 2009

    Expression patterns of 5-HT receptor subtypes 1A and 2A on GABAergic neurons within the spinal dorsal horn of GAD67-GFP knock-in mice.

    • Ya-Yun Wang, Yan-Yan Wei, Jing Huang, Wei Wang, Nobuaiki Tamamaki, Yun-Qing Li, and Sheng-Xi Wu.
    • Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.
    • J. Chem. Neuroanat. 2009 Sep 1;38(1):75-81.

    Abstract5-HT plays an important role in GABA transmission at the spinal cord level. The main purpose of the present article is to find out, which 5-HT receptor subtypes may be involved in the regulation of GABAergic transmission in the spinal dorsal horn, by using the combination of tissue RT-PCR, single-cell RT-PCR and double immunofluorescent staining on the GAD(67)-GFP knock-in mice. The present result showed that 5-HT(1A) receptor subtype mRNA was present on about half of GFP-positive GABAergic interneurons in the spinal dorsal horn, which suggests a role of 5-HT(1A) receptor in GABA-mediated modulation of nociception at the spinal cord level. However, it is unexpected that just a very limited sub-population of the total GABAergic interneurons express 5-HT(2A) receptor mRNA or proteins in the spinal dorsal horn, which suggests that the 5-HT(2A) receptor subtype may not be important for spinal GABAergic effects in nociceptive modulation.

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