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Ann Fr Anesth Reanim · Oct 2008
[Physico-chemical stability and sterility of non-opioid analgesics in solution].
- A Troïtzky, M Tirault, S Lefeuvre, B Lepage, and B Debaene.
- Département d'anesthésie-réanimation, hôpital Jean-Bernard, 2, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France. annetroitzky@aol.com
- Ann Fr Anesth Reanim. 2008 Oct 1;27(10):813-8.
ObjectivesThe combination of non-opioid analgesic drugs (P: paracetamol, K: ketoprofen and N: nefopam) is currently recommended for postoperative pain control. In practice, these analgesics are often administered in the same solution. We investigated the chemical stability and sterility of three mixtures of analgesics (P+K, P+N and K+N).MethodsFor each mixture, concentrations of active principles were measured using high-performance liquid chromatography over 24 hours. These mixtures were cultured for microbiological colonization.ResultsOur study demonstrated chemical and bacteriologic stability of these three mixtures over a 24-hour period. The results allow the use of P+K, P+N and K+N in the same ready to use solution.
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