• Artemisia Papadima, Maria Boutsikou, Emmanuel E Lagoudianakis, Agapi Kataki, Manoussos Konstadoulakis, Loukas Georgiou, Vaggelogiannis Katergiannakis, and Andreas Manouras.
• Laboratory of Surgical Research, 1st Department of Propaedeutic Surgery, Hippokrateio Hospital, University of Athens, 11527 Athens, Greece.
• J Clin Anesth. 2009 Sep 1;21(6):414-21.

Study ObjectiveTo examine the influence of abdominal colectomy with combined general anesthesia and epidural analgesia versus general anesthesia on apoptosis of circulating lymphocytes.DesignProspective, randomized, clinical comparison study.SettingTertiary-care general hospital.Patients40 ASA physical status I and II patients undergoing elective open colectomy for nonmetastatic colon carcinoma.InterventionsPatients were randomly allocated to two groups to receiver either general anesthesia alone (Group G) or general anesthesia combined with epidural analgesia (Group C). Group C comprised 21 patients while 19 patients constituted Group G. All patients underwent median longitudinal laparotomy.MeasurementsBlood samples were collected preoperatively and 24 hours postoperatively for measurement of lymphocyte apoptosis, serum cortisol, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).Main ResultsThere were no differences between the two groups in age, weight, or duration of surgery. No significant alterations in total lymphocyte counts, as well as in lymphocyte subpopulations (early apoptotic, late apoptotic, viable, and necrotic), were observed between the general and combined anesthesia groups. Cortisol, ESR, and CRP were significantly increased postoperatively in both groups. Group C presented with lower serum cortisol levels postoperatively than Group G (b = -5.38, CI95%: -8.72 to -2.05, P = 0.002).ConclusionsEpidural block could not suppress postoperative lymphocyte apoptosis, increases in cortisol, CRP, or ESR compared with general anesthesia.

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