• J Trauma · Jun 2009

    Multicenter Study

    Alcohol and risk of mortality in patients with traumatic brain injury.

    • Jamie R Shandro, Frederick P Rivara, Jin Wang, Gregory J Jurkovich, Avery B Nathens, and Ellen J MacKenzie.
    • Harborview Injury Prevention and Research Center, University of Washington School of Medicine, Seattle, Washington 98104, USA. jshandro@u.washington.edu
    • J Trauma. 2009 Jun 1;66(6):1584-90.

    BackgroundLaboratory and clinical studies demonstrate inconsistent findings on the effect of alcohol on traumatic brain injury (TBI) outcome. The purpose of this study is to use a comprehensive trauma database to determine whether blood alcohol concentration (BAC) is associated with mortality in patients with TBI.MethodsDesignCohort study.SettingEighteen trauma centers and 51 nontrauma centers in the United States.PatientsA total of 1,529 patients aged 18 years to 84 years of age admitted to hospital with TBI between July 2001 and November 2002.ExposureBAC assessed in the index hospital emergency department.OutcomeMortality in-hospital, 90 and 365 days after injury.ResultsAfter adjusting for confounding variables, there was no significant difference for in-hospital, 90-day, and 365-day mortality by BAC.ConclusionsWhen fully adjusted for injury severity, alcohol intoxication is not associated with significantly lower mortality after TBI. The trend toward lower mortality at higher BACs prompts questions about the complex interaction of alcohol and TBI, and warrants further investigation of the possible protective effect of alcohol.

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