• Der Unfallchirurg · Jun 2014

    Review

    [Chemotherapeutic concepts for bone sarcomas].

    • L Kager and S Bielack.
    • Abteilung für Kinder- und Jugendheilkunde, St. Anna Kinderspital, Medizinische Universität Wien, Wien, Österreich.
    • Unfallchirurg. 2014 Jun 1; 117 (6): 517-22.

    BackgroundOsteosarcoma and Ewing sarcoma are the most common chemosensitive sarcomas of the bone.AimDevelopment in chemotherapeutic concepts as well as current and future treatment strategies in osteosarcoma and Ewing sarcoma are presented.MethodsA PubMed search for "Osteosarcoma" and "Ewing sarcoma" was performed, and pertinent results were summarized.ResultsIn both osteosarcoma and Ewing sarcoma, outcomes achieved with multimodal treatment concepts combining conventional chemotherapy and local treatment have reached a plateau of about 70% for 5-year survival rates.DiscussionImproved insights into the molecular biology and genetics of the diseases as well as insights into the interactions between sarcoma cells and the micro-environment and the immune system are necessary to identify novel therapeutic targets in bone sarcomas. Because of the rarity of the diseases, multinational cooperation is essential to evaluate novel therapies in prospective randomized trials.

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