• Anke P C Top, Can Ince, Monique van Dijk, and Dick Tibboel.
• Department of Intensive Care, Erasmus Medical Center-Sophia Children's hospital, Rotterdam, The Netherlands. p.top@erasmusmc.nl
• Crit. Care Med. 2009 Mar 1;37(3):1121-4.

ObjectivesExtracorporeal membrane oxygenation (ECMO) is known to improve cardiorespiratory function and outcome in neonates with severe respiratory failure. In this study, we tested two hypotheses: 1) neonates with severe respiratory failure exhibit alterations of the microcirculation and 2) after ECMO therapy these microcirculatory alterations are improved.DesignSingle-center prospective observational study.SettingIntensive care unit of a level III university children's hospital.PatientsTerm neonates receiving venoarterial ECMO. Control patients with and without respiratory failure.Measurements And Main ResultsThe microcirculation was assessed in the buccal mucosa, using orthogonal polarization spectral imaging, before and after ECMO. Functional capillary density was lower in patients with severe respiratory failure before ECMO (n = 14) compared with control patients (n = 10; p < 0.01). Functional capillary density had increased significantly after ECMO (p < 0.01).ConclusionMicrocirculatory parameters are depressed in neonates with severe respiratory failure and improve significantly following ECMO treatment.

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