• A & A case reports · Apr 2014

    Coronary artery bypass grafting in 2 thrombophilic patients with protein s deficiency.

    • Yen-Michael S Hsu and George J Despotis.
    • From the Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
    • A A Case Rep. 2014 Apr 15;2(8):92-4.

    AbstractIn this report, we review 2 cases of coronary revascularization in patients with a diagnosis of coronary artery disease and preoperative protein S deficiency, an established hypercoagulable condition. In an attempt to normalize protein S levels, fresh frozen plasma was used as the priming fluid for the cardiopulmonary bypass circuit before the initiation of extracorporeal circulation. On the basis of a low risk of bleeding and the theoretical risk of thrombosis, neither patient received intraoperative antifibrinolytic treatment nor did they develop perioperative thrombotic complications.

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