• Paediatric anaesthesia · Jan 1995

    Case Reports

    Nicardipine: perioperative applications in children.

    • J D Tobias, S Lowe, and J K Deshpande.
    • Division of Pediatric Critical Care and Anesthesia, Vanderbilt University, Nashville, Tennessee 37232, USA.
    • Paediatr Anaesth. 1995 Jan 1;5(3):171-6.

    AbstractNicardipine is the first intravenously administered dihydropyridine calcium channel blocker. Its primary physiological actions include vasodilatation with limited effects on the inotropic and dromotropic function of the myocardium. Several reports have documented its use in adult patients for pharmacological control of blood pressure. We present our experience with the perioperative use of nicardipine in children to treat intraoperative hypertension, as an agent for controlled hypotension during spinal fusion and LeFort I maxillary osteotomies and to treat postoperative hypertension. Dosing regimens and possible applications in paediatric anaesthesia are discussed.

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