• Journal of endodontics · Oct 2003

    Randomized Controlled Trial Clinical Trial

    Evaluation of meloxicam (A cox-2 inhibitor) for management of postoperative endodontic pain: a double-blind placebo-controlled study.

    • Mohammad Hosein Nekoofar, Marzieh Sadeghipanah, and Ahmad Reza Dehpour.
    • Endodontics Department, Dental School, Tehran University of Medical Sciences.
    • J Endod. 2003 Oct 1;29(10):634-7.

    AbstractSuccessful management of endodontic pain represents a continuing challenge. The purpose of this randomized, double-blind, placebo-controlled, parallel-group trial was to compare the pain reducing effect of oral preparations of meloxicam, piroxicam, and placebo in endodontic emergency patients. A total of 51 patients who presented to the Tehran University endodontic clinic and one private dental clinic were invited to participate. Patients were asked to evaluate their pretreatment pain with a visual-analog scale. After root canal therapy they were randomly assigned to one of three groups: meloxicam, piroxicam, or placebo. Each patient was sent home with a visual-analog scale to fill out at 8 and 24 h after completion of therapy. The results of this study showed no significant differences between efficacy of meloxicam, piroxicam, and placebo, but a significant effect of the time factor in reducing postoperative pain in all treatment groups was observed.

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