• Ann Clin Transl Neurol · Feb 2014

    Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma.

    • Celine Z Bueche, Cheryl Hawkes, Cornelia Garz, Stefan Vielhaber, Johannes Attems, Robert T Knight, Klaus Reymann, Hans-Jochen Heinze, Roxana O Carare, and Stefanie Schreiber.
    • Department of Neurology, Otto-von-Guericke University Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany.
    • Ann Clin Transl Neurol. 2014 Feb 1;1(2):124-9.

    AbstractThere is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Aβ from the brain and hypertension is a well-known risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.

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