• J Chromatogr A · Jan 2015

    Review

    Microfluidic platform towards point-of-care diagnostics in infectious diseases.

    • Wentao Su, Xinghua Gao, Lei Jiang, and Jianhua Qin.
    • Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
    • J Chromatogr A. 2015 Jan 16;1377:13-26.

    AbstractRapid and timely diagnosis of infectious diseases is a critical determinant of clinical outcomes and general public health. For the detection of various pathogens, microfluidics-based platforms offer many advantages, including speed, cost, portability, high throughput, and automation. This review provides an overview of the recent advances in microfluidic technologies for point-of-care (POC) diagnostics for infectious diseases. The key aspects of such technologies for the development of a fully integrated POC platform are introduced, including sample preparation, on-chip nucleic acid analysis and immunoassay, and system integration/automation. The current challenges to practical implementation of this technology are discussed together with future perspectives.Copyright © 2014 Elsevier B.V. All rights reserved.

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