• Br J Anaesth · Jan 1994

    Randomized Controlled Trial Comparative Study Clinical Trial

    Diamorphine-bupivacaine mixture compared with plain bupivacaine for analgesia.

    • C R Bailey, R Ruggier, and I L Findley.
    • Department of Anaesthetics, St Georges Hospital, London.
    • Br J Anaesth. 1994 Jan 1;72(1):58-61.

    AbstractWe have studied the efficacy of two extradural infusions (10 ml h-1) in 50 patients in active labour. Patients in the diamorphine group (n = 25) received 0.0625% plain bupivacaine 6.25 mg h-1 mixed with 0.005% diamorphine 0.5 mg h-1 and those in the control group (n = 25) received 0.125% plain bupivacaine 12.5 mg h-1. Both groups received intermittent "top-ups" of 0.25% bupivacaine 10 ml when indicated. Although median pain scores during the infusion were similar in both groups, patients in the diamorphine group indicated greater satisfaction with the infusion (88% very satisfied, compared with 52% in the control group (P < 0.02)). There were no differences in the incidence of hypotension, instrumental vaginal delivery, number of "top-ups", duration of the second stage or extent of motor block. However, patients in the diamorphine group had a high incidence of pruritus (44%, compared with 0% in the control group (P < 0.01)).

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