• Holly Elizabeth Perry, Priyanka Prasad, Susy Kirwan, and Yuan Qing Huang.
• Faculty of Health and Environmental Sciences, Auckland University of Technology, New Zealand.
• Transfusion. 2010 Jan 1;50(1):174-7.

BackgroundThe 30-minute rule, whereby intact red blood cell (RBC) products may be returned to stock if returned to 4 degrees C storage within 30 minutes of issue, was established many years ago. It was based on observations that the core temperature of units of whole blood removed from storage temperatures of 1 to 6 degrees C, and left at room temperature, would reach 10 degrees C at between 45 minutes and 1 hour.Study Design And MethodsForty-one units of RBCs resuspended leukoreduced and 8 units of pediatric RBCs resuspended leukoreduced were exposed to ambient temperature for periods of time between 0 and 60 minutes. Core temperatures of all units were measured at 1-minute or 5-minute intervals.ResultsResuspended RBCs units reached a mean core temperature of 10 degrees C at 15 minutes, 12.7 degrees C at 30 minutes, and 15 degrees C at 60 minutes. Pediatric RBCs reached a mean core temperature of 12.8 degrees C at 15 minutes, 15.5 degrees C at 30 minutes, and 17.8 degrees C at 60 minutes.ConclusionIn view of our results, and the range of RBC products now available, it may be timely for blood services to review and reduce the 30-minute rule.

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