• Pain · Oct 2014

    A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.

    • Daniel S Brenner, Judith P Golden, Sherri K Vogt, Ajay Dhaka, Gina M Story, and Robert W Gereau.
    • Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Neuroscience Program, Washington University School of Medicine, St. Louis, MO 63110, USA; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA.
    • Pain. 2014 Oct 1; 155 (10): 2124-33.

    AbstractThe ability to sense and respond to thermal stimuli at varied environmental temperatures is essential for survival in seasonal areas. In this study, we show that mice respond similarly to ramping changes in temperature from a wide range of baseline temperatures. Further investigation suggests that this ability to adapt to different ambient environments is based on rapid adjustments made to a dynamic temperature set point. The adjustment of this set point requires transient receptor potential cation channel, subfamily member 8 (TRPM8), but not transient receptor potential cation channel, subfamily A, member 1 (TRPA1), and is regulated by phospholipase C (PLC) activity. Overall, our findings suggest that temperature response thresholds in mice are dynamic, and that this ability to adapt to environmental temperature seems to mirror the in vitro findings that PLC-mediated hydrolysis of phosphoinositol 4,5-bisphosphate modulates TRPM8 activity and thereby regulates the response thresholds to cold stimuli.Copyright © 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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