• Pain Res Treat · Jan 2012

    Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery.

    • Héctor A Ponce-Monter, Mario I Ortiz, Alexis F Garza-Hernández, Raúl Monroy-Maya, Marisela Soto-Ríos, Lourdes Carrillo-Alarcón, Gerardo Reyes-García, and Eduardo Fernández-Martínez.
    • Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, 42090 Pachuca, HGO, Mexico.
    • Pain Res Treat. 2012 Jan 1;2012:104782.

    AbstractThe aim of this study was to compare the efficacy of diclofenac, for the treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This was a single-center, prospective, randomized, and double-blinded clinical trial. Patients with lower-limb closed fractures rated their pain on a 10 cm visual analog scale (VAS). Patients were then randomized to receive diclofenac or diclofenac plus B vitamins (thiamine, pyridoxine, and cyanocobalamin) intramuscularly twice daily. Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours presurgery and twenty-four hours postsurgical. One hundred twenty-two patients completed the study. The subjects' assessments of limb pain on the VAS showed a significant reduction from baseline values regardless of the treatment group. Diclofenac plus B vitamins combination was more effective to reduce the pain than diclofenac alone. The results showed that the addition of B vitamins to diclofenac increased its analgesic effect. The novelty of this paper consists in that diclofenac and diclofenac plus B vitamins were useful for treatment of acute pain originated by lower-limb fracture and surgery.

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