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Curr Opin Invest Dr · Jul 2007
ReviewAtypical antipsychotic drugs: current issues of safety and efficacy in the management of schizophrenia.
- Divya Vohora.
- Jamia Hamdard (Hamdard University), Faculty of Pharmacy, Department of Pharmacology, New Delhi 110062, India. divyavohora@hotmail.com
- Curr Opin Invest Dr. 2007 Jul 1;8(7):531-8.
AbstractThis review focuses on the comparative safety and efficacy profile of nine atypical antipsychotic drugs (amisulpride, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone and zotepine), which may ultimately affect the therapeutic options available for patients with schizophrenia. These antipsychotic compounds differ markedly in their potential to impact a number of quality-of-life measures. Furthermore, their differential effects on anxiety disorders, treatment-resistant depressive illness, cognitive functions and manic disorders may influence the selection of atypical antipsychotics for conditions associated with schizophrenia. The possible relevance of these parameters in evaluating the risk/benefit equation and probable involvement of varying receptor mechanisms is also discussed.
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