• Ryan S Smith and John M Murkin.
• Department of Anesthesia, McMaster University, Hamilton; Department of Anesthesiology and Perioperative Medicine, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.
• J. Cardiothorac. Vasc. Anesth. 2014 Oct 1;28(5):1217-20.

ObjectiveCardiac surgery and cardiopulmonary bypass are associated with release of inflammatory mediators and microcirculatory alterations that result in organ dysfunction. Near-infrared spectroscopic measurement of tissue oxygen saturation (StO2) and the vascular occlusion test (VOT) were utilized in a study of elective cardiac surgical patients as a novel, noninvasive method of assessing microcirculatory vasoreactivity during nonpulsatile cardiopulmonary bypass (CPB). The objective of this pilot study was to determine whether differences in microcirculatory function and vasoreactivity could be measured in cardiac surgery using StO2 and VOT.DesignA prospective, observational trial.SettingTertiary care teaching hospital.ParticipantsThirteen patients undergoing elective cardiac surgery using tepid, nonpulsatile cardiopulmonary bypass.InterventionsPatients had continuous regional oxygen saturation monitoring using near-infrared spectroscopy and vascular occlusion tests performed in the perioperative period before, during, and after cardiopulmonary bypass.Measurements And Main ResultsOcclusion slope and hyperemic area did not vary significantly. Mean reperfusion slope was significantly lower during cardiopulmonary bypass (2.4%/second) compared to before and after bypass (4.1 and 3.5%/second, respectively). Reperfusion slope decreased as a function of CPB duration.ConclusionsThis pilot study demonstrates a significant difference in reperfusion slopes during cardiopulmonary bypass when compared to prebypass and postbypass, suggesting impaired peripheral microvascular reactivity. Reperfusion slopes also exhibited a successive decline with duration of CPB, implying worsening microcirculatory dysfunction that returned to baseline values in all patients within 1 hour of separation from CPB. This noninvasive technique has potential to optimize circulatory parameters during cardiopulmonary bypass.Copyright © 2014 Elsevier Inc. All rights reserved.

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